Personal Information

Dr. Ritesh Singh

Assistant Professor
Department of Chemistry

PhD (CSIR-CDRI, Lucknow), Post-doc (University of Rochester, NY, USA); (UNIST, KOREA); (Kyoto Prefectural University of Medicine, Kyoto, JAPAN)

ritesh.singh@curaj.ac.in

a) Development of sustainable methods to access bio-relevant scaffolds using

1) C-H bond Functionalization

2) Aryne Chemistry

b) Chemo-enzymatic Synthesis

c) Chemical Biology (Epigenetic Modulators)

Webpage: https://sites.google.com/view/ritesh-lab/home?authuser=0

 

B.Sc.: University of Lucknow 

M.Sc.: University of Lucknow 

Ph.D. : CSIR-Central Drug Research Institute, Lucknow (JNU, New Delhi)

Post-doc:  University of Rochester, USA

                 Ulsan National Institute of Science and Technology (UNIST), Ulsan, KOREA

                 Kyoto Prefectural University of Medicine (KPUM), Kyoto, JAPAN  (as JSPS Fellow)

A) Development of novel synthetic strategies to access biologically relevant scaffolds and natural products via C-H bond functionalization. In this area, efforts are oriented towards the development of sustainable approaches to achieve our goal.

B) Development of metal-free approaches to synthesize pharmaceutical important scaffolds. Efforts are oriented to bring innovative strategies to achieve our goal.

C) Utilization of developed methods to construct molecules for chemical biology/medicinal chemistry to solve the unmet need in the area of drug research discovery programs.

 

For more details, kindly visit

https://sites.google.com/view/ritesh-lab/home?authuser=0

S. No. Authors Title of Article Journal/Conference Details Journal/Conference Publication Year
1 1
  1. Deeksha, Elagandhula Sathish, Kiran, and Ritesh Singh*; Access to Sterically Hindered Thioethers (α-Thioamides) Under Mild Conditions Using α-Halohydroxamates: Application toward 1,4-Benzothiazinones and 4,1-Benzothiazepinones. J. Org. Chem., 2023, 88, 901–908.
  2. Elagandhula Sathish, Ashis Kumar Gupta, Deeksha, Sandeep Kumar Mishra, Devesh M. Sawant, and Ritesh Singh*; Heteroarylation of Congested α-Bromoamides with Imidazo-heteroarenes and Indolizines via Aza-oxyallyl Cations: Enroute to Dibenzoazepinone and Zolpidem Analogs. J. Org. Chem., 2022, 87, 14168–14176.
  3. Deeksha, and Ritesh Singh*; Aza-oxyallyl Cations and Their Applications in (3+m) Cycloaddition Reactions. Eur. J. Org. Chem., 2022, 2022, e202201043. (VIP article and Front Cover page)
  4. Yosuke Ota, Yukihiro Itoh, Takashi Kurohara, Ritesh Singh, Elghareeb E. Elboray, Chenliang Hu, Farzad Zamani, Anirban Mukherjee, Yuri Takada, Yasunobu Yamashita, Mie Morita, Mano Horinaka, Yoshihiro Sowa, Mitsuharu Masuda, Toshiyuki Sakai, and Takayoshi Suzuki*; Cancer-Cell-Selective Targeting by Arylcyclopropylamine–Vorinostat Conjugates. ACS Med. Chem. Lett. 2022, 13, 1568–1573.
  5. Anirban Mukherjee, Ritesh Singh, Kishor D Mane and Gourab Kanti Das; Regioselectivity in Metalloradical Catalyzed C-H bond activation: A Theoretical Study. J. Organomet. Chem., 2022, 957, 122179.
  6. Muthuraj Prakash, Yukihiro Itoh,* Yoshie Fujiwara, Yukari Takahashi,† Yuri Takada, Paolo Mellini, Elghareeb E. Elboray, Mitsuhiro Terao, Yasunobu Yamashita, Chika Yamamoto, Takao Yamaguchi, Masayuki Kotoku, Yuki Kitao, Ritesh Singh, Rohini Roy, Satoshi Obika, Makoto Oba, Dan Ohtan Wang and Takayoshi Suzuki*; Identification of Potent and Selective Inhibitors of Fat Mass Obesity-Associated Protein Using a Fragment-Merging Approach. J. Med. Chem., 2021, 64, 15810–15824.
  7. Elagandhula Sathish, Ashis K. Gupta, Sophiya Goyal, and Ritesh Singh*; 3d-transition metal catalyzed C–H to C–N bond formation: An update. Tetrahedron, 2021, 100, 132474.
  8. Arshad J. Ansari, Ayushi Yadav, Anirban Mukherjee, E. Sathish, Kommu Nagesh and Ritesh Singh*; Metal Free Amination of Congested and Functionalized Alkyl Bromide at Room Temperature. Chem. Commun., 2020, 56, 4804-4807.
  9. Anirban Mukherjee, Arshad J. Ansari, S. Rajagopal Reddy, Gourab Kanti Das, and Ritesh Singh*; Mechanistic Investigations for the Formation of Active Hexafluoroisopropyl Benzoates Involving Aza-Oxyallyl Cation and Anthranils. Asian. J. Org. Chem., 2020, 9, 2136-2143.
  10. Ritesh Singh* and Anirban Mukherjee; Metalloporphyrin Catalyzed C-H Amination. ACS Catalysis, 2019, 9, 3604-3617.
  11. A.V.G. Prasanthi, Samiyara Begum, Hemant Kumar Srivastava, Sandip Kumar Tiwari, and Ritesh Singh*; Iron-Catalyzed Arene C—H Amidation using Functionalized Hydroxyl Amines at Room Temperature. ACS Catalysis, 2018, 8, 8369–8375.
  12. Ritesh Singh,* Kommu Nagesh, Doddapaneni Yugandhar, and A.V.G. Prasanthi; Metal and Oxidant Free Modular Approach to Access N-alkoxy Oxindoles via Aryne Annulation . Org. Lett., 2018, 20, 4848–4853.
  13. Ritesh Singh,* Kommu Nagesh, and Matam Parameshwar; Rhodium(II)-Catalyzed Undirected and Selective C(sp2)−H Amination en Route to Benzoxazolones. ACS Catalysis, 2016, 6, 6520-6524.

 

Postdoctoral & Doctoral Research

  1. Simone Giovani#, Ritesh Singh# and Rudi Fasan; Efficient conversion of primary azides to aldehydes catalyzed by active site variants of Myoglobin. Chemical Science, 2016, 7, 234-239. (# Ist Co-author; equal contribution)
  2. Ritesh Singh, Joshua N Kolev, Philip A Sutera and Rudi Fasan; Enzymatic C(sp3 )–H Amination: P450-Catalyzed Conversion of Carbonazidates into Oxazolidinones. ACS Catalysis, 2015, 5, 1685–1691.
  3. Ritesh Singh, Melanie Bordeaux and Rudi Fasan; P450-Catalyzed Intramolecular sp3 C–H Amination with Arylsulfonyl Azide Substrates. ACS Catalysis, 2014, 4, 546–552.
  4. Melanie Bordeaux, Ritesh Singh and Rudi Fasan; Intramolecular C(sp3)—H amination of arylsulfonyl azides with engineered and artificial myoglobin-based catalysts. Bioorganic & Medicinal Chemistry, 2014, 22, 5697-5704.
  5. Jyotsana Singh#, Ritesh Singh#, Preeti Gupta, Smita Rai, Asha Ganesher, Preethi Badrinarayan, G. Narahari Sastry, Rituraj Konwar and Gautam Panda; Targeting progesterone metabolism in breast cancer with L-proline derived new 14-azasteroids; Bioorganic & Medicinal Chemistry, 2017,25, 4452-4463. (# Ist co-author; equal contribution)
  6. Ritesh Singh and Gautam Panda; Application of Nazarov type electrocyclization to access [6,5,6] and [6,5,5] core embedded new polycycles: an easy entry to tetrahydrofluorene scaffolds related to Taiwaniaquinoids and C-nor-D homosteroids; Org. Biomol. Chem., 2011, 9, 4782-4790. (Front Cover page)
  7. Ritesh Singh and Gautam Panda; Scandium triflate-catalyzed one-pot domino approach towards general and efficient syntheses of unsymmetrical 9-substituted xanthene derivatives. Org. Biomol. Chem. 2010, 8, 1097-1105.
  8. Ritesh Singh, Maloy Kumar Parai and Gautam Panda; Application of Nazarov cyclization to access [6-5-6] and [6-5-5]tricyclic core embedded new heterocycles: an easy entry to structures related to Taiwaniaquinoids. Org. Biomol. Chem., 2009, 7, 1858-1867.
  9. Ritesh Singh and Gautam Panda; An Overview of Synthetic approaches for Heterocyclic steroids. Tetrahedron 2013, 69, 2853-2884. [IF: 2.45]
  10. Ritesh Singh and Gautam Panda; L-Proline derived nitrogenous steroidal systems: an asymmetric approach to 14-azasteroids. RSC Advances 2013, 3, 19533-19544.
  11. Ritesh Singh, Maloy Kumar Parai, Sankalan Mondal and Gautam Panda; Contiguous generation of Quaternary and Tertiary Stereocenters: One Pot Synthesis of Chroman Fused S-proline Derived Chiral Oxazepinones. Synthetic Communications, 2013, 43, 253-259.
  12. Sajal Kumar Das, Ritesh Singh and Gautam Panda; A New Synthetic Route to Unsymmetrical 9-Arylxanthenes; Eur. J. Org. Chem. 2009, 4757-4761.
  13. Shagufta, Ritesh Singh, and Gautam Panda; Synthetic studies towards steroid–amino acid hybrids; Indian Journal of Chemistry 2009, 48B, 989-995.

1) C-H bond Functionalization to Access Bio-relevant Scaffolds (DST/INSPIRE/04/2015/001075) from DST INSPIRE (Rs. 35 lakh): 2015-2021 

2) Bio-catalytic (Hetero)aromatic C-H bond amination (PDF/2020/000997) from DST (Rs. 19.2 lakh): 2020-2022

(*mentor of Dr. Asish K. Gupta)

2) Synthetic Exploration of Aza-oxyallyl cation for Rapid Access to Bio-relevant Fluorinated Scaffolds and their Biological Evaluation- (CRG/2020/001633)  from DST SERB (Rs. 54.7 lakh): 2020-2023

Attended

  1. Synthetic Exploration of Aza-oxyallyl Cation Towards Oxindoles and 1,4-Benzodiazepines, 25th ISCB International Conference (ISCBC-2019), NIRMA University, Ahmedabad, 22-26 Jan. 2020. (Invited lecture)
  2. Attended the NOST-XXI, November 25-28, 2021, The Leela Palace, Chennai. (Invited)
  3. Synthetic Exploration of Aza-oxyallyl Cation to Access Oxindoles, 1,4-Benzodiazepinones and Congested α-Aminoamides, 8th International symposium on “Current Trends in Drug Discovery Research” (CTDDR-2022), CSIR-Central Drug Research Institute, Lucknow, 22-24 March 2022. (Invited)
  4. Contemporary Facets in Organic Synthesis (CFOS-2022), IIT Roorkee, 01-04 Dec., 2022. Invited talk “Aza-oxyallyl Cation as a Linchpin to Access Biologically Relevant N-Scaffolds”. (Invited lecture)
  5. Frontiers at the Chemistry - Allied Sciences Interface (FCASI-2023), University of Rajasthan, 20-21 April, 2023. Invited talk “Harnessing Aza-oxyallyl Cations to Access Biologically Relevant N-Scaffolds” (Invited Lecture)
Title Attachment File Other Link
Singh Research Group PDF icon Dr. Ritesh Singh_CV.pdf https://sites.google.com/view/ritesh-lab/home?authuser=0