Personal Information

Dr. Sagar S. Barale

Assistant Professor
Department of Microbiology

M.Sc. (Microbiology), Ph. D (Microbiology, Shivaji University, Kolhapur, Maharashtra) NET, SET, GATE.

sagar.barale@curaj.ac.in

8698825817

Infectious disease

Antimicrobial peptides

Antibiotic resistance 

Structural Bioinformatics

Awards and Fellowships:

Research Assistant, DST-PURSE-II, at Department of Microbiology, Kolhapur (2018-2019)

Award of CM-SRF 2019 Chief Minister Special Research Fellowship, SARTHI, Maharashtra, India

Qualified GATE examination with 99.59% tile AIR-52

Qualified CSIR NET (National Eligibility Test) LS,

Qualified CSIR NET (National Eligibility Test) LS

Qualified Maharashtra State Eligibility Test (SET)

My research interest is to understand molecular evolution of infectious agents such as antibiotic resistance mechanisms for identification of drug targets and novel therapeutic agents. My Ph. D research mainly focuses on the isolation of antimicrobial peptides targeting drug resistance bacteria. My doctoral research also focuses on the peptides aggregation and their structure activity relationship in neurodegenerative disorder. Expertise in structural bioinformatics, experimental microbiology, and molecular biology.       

S. No. Authors Title of Article Journal/Conference Details Journal/Conference Publication Year
1 1
  1. Sagar S. Barale, Savaliram G Ghane, Kailas D. Sonawane. (2022) Purification and characterization of antibacterial surfactin isoforms produced by B. velezensis SK. AMB Expr, 12, 7. 
  2. Sagar S. Barale, Rishikesh S. Parulekar, Prayagraj M. Fandilolu, Maruti J. Dhanavade and Kailas D. Sonawane. (2019) Molecular Insights into Destabilization of Alzheimer’s Aβ Protofibril by Arginine Containing Short Peptides: A Molecular Modeling Approach. ACS Omega, 892-903. 
  3. Sagar U. Jadhav, Rushikesh P. Dhavale, Rakesh P. Dhavale, Manish S.Bhatia, Maruti J. Dhanavade, Sagar S. Barale, Sachin Pathak, Vinayak G. Parale ,Kailas D. Sonawane.  (2023) Exploring anticancer potential of nintedanib conjugated magnetic nanoparticles: In-vitro and in-silico studies. Journal of Drug Delivery Science and Technology, 104213.
  4. Abhijeet P. Herwade, Sagar S. Barale, Kailas D. Sonawane, and Pankaj K. Pawar. (2022) In vivo developmental studies of Helicoverpa armigera and in silico molecular interactions with trypsin reveal the bio-insecticidal potential of trypsin inhibitor (SSTI) isolated from Solanum surattense. Int. J. Biol. Macromol, 223, 335-345. 
  5. Manoj Thakur, Rishikesh S. Parulekar, Sagar S. Barale, Kailas D. Sonawane, Kalappa Muniyappa. (2022) Interrogating the substrate specificity landscape of UvrC reveals novel insights into its non-canonical function. Biophys J. 121, 3103-3125.
  6. Navanath Kumbhar, Snehal Nimal, Sagar Barale, Subodh Kamble, Rohit Bavi, Kailas Sonawane, Rajesh Gacche. (2022) Identification of novel leads as potent inhibitors of HDAC3 using ligand-based pharmacophore modeling and MD simulation. Scientific Reports, 12, 1712. 
  7. Subodh Kamble, Sagar Barale, Maruti Dhanavade, Kailas Sonawane. (2021) Structural significance of Neprylysin from Streptococcus suis GZ1 in the degradation of Aβ peptides a causative agent in Alzheimer’s disease. Computers in Biology and medicine, 136, 104691.
  8. Kailas D. Sonawane, Sagar S. Barale, et al. (2021) Structural insights and inhibition mechanism of TMPRSS2 by experimentally known inhibitors Camostat mesylate, Nafamostat and Bromhexine hydrochloride to control SARS-Coronavirus-2: A molecular modeling approach. Informatics in Medicine Unlocked, 24, 100597.
  9. Kailas D. Sonawane, Sagar S. Barale, et.al. (2020) Homology Modeling and Docking Studies of TMPRSS2 with Experimentally Known Inhibitors Camostat Mesylate, Nafamostat and Bromhexine Hydrochloride to Control SARS-Coronavirus-2. ChemRxiv. Preprint).
  10.  Rishikesh S. Parulekar, Sagar S. Barale, Sonawane, D. Kailas. (2019) Antibiotic resistance mechanism of novel aminoglycoside phosphotransferase APH (5) from B. subtilis subsp subtilis strain RK: A combined in-vitro and in-silico approach. Brazilian Journal of Microbiology, 50, 887–898. (IF: 2.214).
  11.   Prakash Bansode, R. Anantacharya, Maruti Dhanavade, Subodh Kamble, Sagar Barale, Kailas Sonawane, Nayak D. Satyanarayan, Gajanan Rashinkar (2019) Evaluation of drug candidature: In silico ADMET, binding interactions with CDK7 and normal cell line studies of potentially anti-breast cancer enamidines. Computational Biology and Chemistry, 83, 107124.  
  12.   Sneha B. Paymal, Sagar S. Barale, Shirishkumar V. Supanekar, Kailas D. Sonawane. (2023) Structure based virtual screening, molecular dynamic simulation to identify the oxadiazole derivatives as inhibitors of Enterococcus D-Ala-D-Ser ligase for combating vancomycin resistance. Computers in Biology and Medicine, 159, 10696
  13.   Ali A. M, Barale S. S, Kamble S. A, Paymal S. B, Sonawane K. D (2023) Molecular insights into the inhibition of early stages of Aβ peptide aggregation and destabilization of Alzheimer’s Aβ protofibril by dipeptide D-Trp-Aib: a molecular modelling approach. Int J Biol Macromol 242(3):124880.
  14.   V. S. Patil, S. N. Labade, S. S. Barale, A. S. Salunkhe, N. S. Gaikwad, S. S. Sawant and R. K. Jadhav. (2023) Spectroscopic and Docking Studies on Binding of Bovine Serum Albumin with Antipsychotic Fluphenazine Drug. Eur. Chem. Bull.12(12), 1826-1840.
  15.   Kamble, S.A., Sagar S. Barale, Mohammed, A.A. et al. (2024) Structural insights into the potential binding sites of Cathepsin D using molecular modelling techniques. Amino Acids. 56, 33.
  16.   Vidya Patil, Sagar Barale, Pratibha Patil, Smita Deore, Kishor Kakde, Ranjana Jadhav. (2024) Spectroscopic Investigations of Conformational Change in Bovine Serum Albumin (BSA) with Rising Concentration of a Mood Stabilizing Drug: Lamotrigine. Afr.J.Bio.Sc. 6(15).
  17.   Sneha B. Paymal, Sagar S. Barale, Shirishkumar V. Supanekar, Kailas D. Sonawane. Kiran D. Pawar. (2025) Overexpression, Purification, and Biochemical Characterization of the vanC2 d-Ala-d-Ser Ligase from Enterococcus casseliflavus SSK and Its Inhibition by an Oxadiazole Derivative. ACS Omega. 3;10(14):14390-14402.
  18.   Mohammed AA, Barale SS, Dhotare PS, Sonawane KD. Polymyxin‑B as a novel inhibitor of amyloid beta aggregation: computational insights and experimental validation. J Mol Struct. 2025; 1349:3. 
  19.   Ahmed, S., Barale, S.S., Kamble, R.S. et al. Mechanistic insights into amyloid β fibril disruption by ginsenosides through molecular dynamics simulations. Netw Model Anal Health Inform Bioinforma. 2026;15, 45.

 

Book Chapters:

  1. Navanath M. Kumbhar, M.A. Aparna, Snehal K. Nimal, Pallavi Shewale, Sagar Barale, Rajesh Gacche, Chapter 17 - New targets for old drugs: drug repurposing approach for accelerating the drug discovery engine with minimum financial inputs, Editor(s): Surya Nandan Meena, Vinod Nandre, Kisan Kodam, Ram Swaroop Meena, In Progress in Biochemistry and Biotechnology, New Horizons in Natural Compound Research, Academic Press, 2023, Pages 315-349, ISBN 9780443152320.

Attended

  1. Sagar S. Barale, Savaliram G. Ghane and Kailas D. Sonawane. Purification and characterization of surfactin and iturin produced by B. velezensis SK. International Conference on Infectious Diseases and Immunopathology (IDIP-2021), Organized by Department of Biotechnology, Savitribai Phule Pune University 22nd to 24th April 2021.
  2. Sagar S. Barale, Rishikesh S. Parulekar, Prayagraj M. Fandilolu & Kailas D. Sonawane. “Molecular insights into destabilization of Aβ protofibril by short peptide containing arginine: A molecular modeling approach ” in “Symposium on Accelerating Biology 2019 Towards Thinking Machines”, organized by Bioinformatics group, Center for Development of Advanced Computing C-DAC Pune, India 5-7th Feb 2019.
  3. Sagar S. Barale, Rishikesh S. Parulekar, Prayagraj M. Fandilolu & Kailas D. Sonawane. “Molecular insights into destabilization of Aβ protofibril by short peptide containing arginine” in “Symposium on Accelerating Biology 2018 Digitizing life”, organized by Bioinformatics group, Center for Development of Advanced Computing C-DAC Pune, India 9-11th January 2018.
  4. National conference -2019: Research and innovations in healthcare & Buisiness Management Organised by Rashtriya Shikshan Mandal’s CDGIM, Pune, 5-6 November 2019.
  5. One-week Capacity-Building Program on Technology-Enabled Learning, organized by the Central University of Rajasthan in association with NITTTR, Bhopal. (18.08.2025 –22.08.2025)
  6. One week, outcome-based curriculum Development, Training program in association with NITTTR Bhopal, organized by Central University of Rajasthan. (16.12.2024 –20.12.2024)
  7. One week, Curriculum Development Process, Design, Evaluation and Implementation, Training program in association with NITTTR Bhopal, organized by Central University of Rajasthan. (09.09.2024 –13.09.2024).
  8. Three-day Face-to-Face FDP on the theme “Inculcating Universal Human Values in Technical Education” organized by All India Council for Technical Education (AICTE) at Central University of Rajasthan, from 21st October to 23rd October 2024
  9. Four-week Faculty induction/ Orientation program at Ramanuj College, University of Delhi, 22 January to 20 February 2024.
  10.  Research paper presentation entitled “Purification and characterization of antibacterial surfactin isoforms produced by B. velezensis SK” was presented at Advances in Biochemical Sciences: Basic to Translational Research, Central University of Rajasthan, Department of Biochemistry, School of Life Sciences. (20 and 21St March 2024).
  11.  One-day SERB-sponsored Research Training on ‘Cell culture Techniques and Analytical methods for Cancer Research’ on 19th March 2024 at Central University of Rajasthan.
  12.  One-day SERB-sponsored Research Training on ‘Molecular Techniques in Microbiological Research’ on 22nd March 2024 at Central University of Rajasthan