Personal Information
Dr. Joydeep Aoun
Assistant Professor
B.Sc. Physiology(H) & M.Sc.Biochemistry- Calcutta University; Ph.D. - Biochemistry (ICMR-NICED/Calcutta University, Kolkata); Post-Doctoral Training - National Institute of Health (NIH), Bethesda, USA ; University of Nevada, Reno, USA
9836261752
I am an accomplished electrophysiologist and cell biologist with over 12 years of expertise in epithelial and smooth muscle physiology. My dedication to this field drives my research and contributions, and I am committed to advancing our understanding of these vital areas.
I am excited to announce the launch of my lab, "Membrane Transport and Trafficking." Our research will delve into the dynamic fields of electrophysiology and cell biology, and I have 3 to 4 promising projects with strong preliminary data waiting for exploration......
Suppose you are a hardworking student with a background in Physiology, Zoology, Biochemistry, or any Life Sciences, and are eager to embark on a Ph.D. journey to contribute to cellular and preclinical disease models (animal models). In that case, I invite you to reach out for a discussion!
I also warmly welcome students eligible for the DST-Inspire JRF program, particularly those with a compelling project proposal, as well as those from backgrounds in Food and Nutrition.
We are working on developing a new insect model to study cell biology as a substitute for Drosophila...!!!
Research Interests:
- Membrane transport (Electrophysiology) and trafficking.
- Ca2+ and cAMP signaling, at the Membrane Contact Site (MCS)
- Regulation of Membrane Transport and Tight Junction by Microbiome.
- Secretory Epithelia and Smooth Muscle-Linked Disorders.
- Assistant Professor - Department of Biochemistry, Central University of Rajasthan, Ajmer(April 2025 onwards)
- Visiting Fellow - National Institute of Dental and Craniofacial Research(NIDCR) / National Institute of Health(NIH), MD, USA (Spt'2019 - April'2025). Study topic - Epithelial Signaling and Transport.
- Post-doctoral Fellow - Department of Pharmacology, University of Nevada, Reno School of Medicine(UNR), NV, USA (Spt'2018 - Aug'2019). Study topic - Smooth muscle E-C coupling.
- Doctoral Fellow: Pathophysiology Division, National Institute of Cholera and Enteric Diseases (ICMR-NICED, Kolkata, India). Study topic -Intestinal Ion Transport and Barrier Function.
- CSIR - UGC NET - JRF, ICMR - JRF, GATE
- Project Fellow at National Institute of Biomedical Genomics(NIBMG), Kalyani & Presidency University, Kolkata, WB (2013)
- Guest Lecturer of Biochemistry at UG level Heralal Majumder College for Women & Vidyasagar College, Kolkata (2011-2012).
- M.Sc. in Biochemistry(Bullygunge Science College, Calcutta University, 2009-2011)
- B.Sc. in Physiology (Hons) (City College, Calcutta University, 2006-2009).
- Dr. Aoun is a trained electrophysiologist cum cell biologist. He is the first person in the field to discover the “pathophysiological role of TMEM16F or ANO6 (Cl- channel) in intestinal ion transport and physiological role of TMEM16A or ANO1( Cl- channel) in smooth muscle E-C coupling. He also worked on developing universal anti-diarrheal therapy.
- He has a long-term interest in lipid regulation of membrane transport and trafficking. Now it's been evident that membrane contact sites like ER-PM or ER-Mitocondria contact sites are the hub of cellular signaling events(e.g, Ca2+ and cAMP signaling). These signaling nanodomains are highly dynamic architectures that modulate the channels and transporters' function during physiological and pathophysiological conditions.
- Current research interest is the role of membrane lipids and lipid transporters in the orchestration of cAMP and Ca2+ signaling, regulation of membrane transport and trafficking.
| S. No. | Authors | Title of Article | Journal/Conference Details | Journal/Conference | Publication Year |
|---|---|---|---|---|---|
| 1 | ¶Joydeep Aoun, ¶Mikio Hayashi, ¶ Irshad Ali Sheikh, Paramita Sarkar, Tultul Saha, Rajsekhar Bhowmick, Tanaya Chatterjee, Pinak Chakrabarti, Manoj K Chakrabarti , and Kazi Mirajul Hoque. | Anoctamin 6 Contributes to Cl- Secretion in Accessory Cholera Enterotoxin (Ace) Stimulated Diarrhoea: An Essential Role for PIP2 signalling in Cholera. | J Biol Chem 2016 291(52) 26816 - 26836. (IF- 5.48) ¶ Authors share equal contributions.https://doi.org/10.1074/jbc.M116.719823 | Journal | 2016 |
| 2 | Joydeep Aoun*, Elizabeth Akin*, Katie Mayne, Julius Baeck, Michael D. Young, Brennan Sullivan, Kenton M. Sanders, Sean M. Ward, Simon Bulley, Jonathan H. Jaggar, Scott Earley, Iain A. Greenwood, and Normand Leblanc. | ANO1, CaV1.2 and IP3R Form a Localized Unit of EC-Coupling in Mouse Pulmonary Arterial Smooth Muscle. | Journal of General Physiology (2023) 155 (11): e202213217. (IF ~ 4) * Authors share equal contributions. https://doi.org/10.1085/jgp.202213217 | Journal | 2023 |
| 3 | 3. Ayon RJ.,1 Hawn MB., Aoun J, Wiwchar M, Forrest AS., Cunningham F, Singer CA., Valencik ML., Greenwood IA., Leblanc N. | Molecular mechanism of TMEM16A regulation: role of CaMKII and PP1/ PP2A. | American Journal of Physiology Cell Physiol 317: C1093–C1106, 2019 | Journal | 2019 |
| 4 | 2. Paramita Sarkar, Tultul Saha, Irshad Ali Sheikh, Subhra Chakraborty, Joydeep Aoun, Manoj Kumar Chakrabarti, Vazhaikkurachi M. Rajendran, Shanta Dutta, Kazi Mirajul Hoque. | Zinc ameliorates barrier intestinal barrier dysfunctions by reinstating claudin 2 and 4 on the membranes in Shigellosis. | American Journal of Physiology – Gastrointestinal and liver physiology 2019 Feb 1; 316 (2): G229-G246. (IF 3.61) | Journal | 2019 |
| 5 | 4. Saha, Tultul; Aoun, Joydeep; Hayashi, Mikio; Ali, Sheikh Irshad; Sarkar, Paramita; Bag, Prasanta Kumar; Leblanc, Normand; Ameen, Nadia; Woodward, Owen M; Hoque, Kazi MirajuI. | Intestinal TMEM16A control luminal chloride secretion in an NHERF1 dependent manner. | Biochemistry and Biophysics Reports.https://doi.org/10.1016/j.bbrep.2021.100912 | Journal | 2021 |
| 6 | Saha Tultul, Aoun Joydeep, Sarkar Paramita, Bourdelais Andrea J., Baden Daniel G., Leblanc Normand, Hamlyn John M., Woodward Owen M., and Kazi Mirajul Hoque. | Cucumis sativus extract elicits chloride secretion by stimulation of the intestinal TMEM16A ion channel. | Pharmaceutical Biology 2021 VOL. 59, NO. 1, 1006–1013. https://doi.org/10.1080/13880209.2021.1949357 | Journal | |
| 7 | Lee, Min Goo; Kim, Yonjung; Jun, Ikhyun; Aoun, Joydeep; Muallem, Shmuel | Molecular Mechanisms of Pancreatic Bicarbonate Secretion | Pancreapedia: The Exocrine Pancreas Knowledgebase, 2020 | Book Chapter | 2020 |
| 8 | 1. Aoun J, Mayne K, Baeck J, Sanders KM., Ward SM., Greenwood IA., Bulley SA., Jaggar JH., Earley S, Leblanc N. | ANO1, CaV1.2, and IP3R Form a Functional Unit of Excitation Contraction Coupling during Agonist-Mediated Contraction of Mouse Pulmonary Arterial Smooth Muscle. | [Biophysical Journal 2020 118 (3), 563a-564a] | Conference | 2020 |
| 9 | 2. Paramita Sarkar, Tultul Saha, Joydeep Aoun, Subhra Chakraborty, Manoj Kumar Chakraborti, Shanta Dutta, and Mirajul Kazi. | Evidence that Zinc Deficiency Impairs Gut Epithelial Barrier and intestinal Immunity. | The FASEB Journal. 2018.vol. 32 no. 1 Supplement 747.16. | Conference | 2018 |
| 10 | 3. Mirajul H. Kazi, Joydeep Aoun, Paramita Sarkar, Tultul Saha, Hemanta Koley, Vazhaikkurachi M. Rajendran, Shanta Dutta. | Efficacy and safety of TRAM-34 over Zinc in secretory diarrhea of endotoxin stimulation. | Gastroenterology. 2018. 154(6): S-53. | Conference | 2018 |
| 11 | A. Sheikh, J. Aoun, P. Sarkar, T. Saha, M.H. Kazi. | Recombinant accessory cholera enterotoxin of Vibrio cholerae activates ANO6 via RhoA-ROCK-PIP2 signaling to induce secretory diarrhea. | Int J Infect dis 2016. 45S (1):44. | Conference | 2016 |
| 12 | P. Sarkar, A. Sheikh, T. Saha, J. Aoun, M.H. Kazi. | Zinc restores altered intestinal ion-transport, barrier functions, and counteract inflammatory mediators induced by Shigella infection in T84 cells. | Int J Infect dis 2016. 45S (1): 48. | Conference | 2016 |
| 13 | 6. Irshad Ali Sheikh, Paramita Sarkar, Tultul Saha, Joydeep Aoun, Mirajul Kazi. | Epac 1 control intestinal barrier function by regulating JAM-A trafficking via the Rap2C-TNIK pathway. | J gastro and hept 2014. 29(Suppl. 3) 1-332. | Conference | 2014 |
| 14 | J Aoun, M Ahuja, S Muallem | Phosphatidyl Serine (PtdSer) Scramblase TMEM16F (ANO6): a novel mediator and potential therapeutic target in pancreatitis | Journal PANCREAS(2024/11/1 Vol 53, Issue 10), LIPPINCOTT WILLIAMS & WILKINS. Conference American Pancreatic Association meeting 2024. Maui, Hawaii, USA. | Conference | 2024 |
Attended
1. Invited talk as an early-career young scientist - Fortries in disease biology 2025, IISER- Kolkata, India
2. Invited talk as an early-career young scientist - Preclinical model of disease biology 2024, IISER- Kolkata, India
3. Poster Presentation American Pancreatic Association - 2024, Hawaii, USA
4. Poster Presentation Gordon Research Conference - Salivary
and Exocrine Gland Biology 2023 CA, USA
5. NIH Research Festival 2023 and 2024, NIH, Bethesda, USA
| Title | Attachment File | Other Link |
|---|---|---|
 Joydeep Aoun NIH Biosketches.pdf |
