Personal Information

Prof. Inshad Ali Khan

Professor and Head

MSc (Biological Sciences); PhD (Biological Sciences, AIIMS/Jamia Millia Islamia, New Delhi); GATE; DHR visiting Scientist at NIAID, NIH, USA; NASI-Reliance Platinum Jubilee award Specialization: Infectious Diseases drug discovery

inshad@curaj.ac.in

  • Anti-infective research, identification of novel pharmacophores.
  • Antimicrobial resistance and microbial efflux pumps.
  • New drug targets and immunotherapeutics for M.tuberculosis.
  • Regulation of M. tuberculosis gene expression.
  • Oral microbiology
  • Phytopharamaceutical and NCE drug development

Educational Qualifications

1996- PhD thesis “Molecular fingerprinting of Salmonella typhi, Department of Microbiology, AIIMS, New Delhi. Registered for PhD at Jamia Millia Islamia, New Delhi.

 

1992- MSc Biological Sciences, Jamia Millia Islamia, New Delhi

 

1990- BSc in “Botany, Zoology, Chemistry”, Zakir Hussain College, Delhi University

 

Awards, Fellowships, memberships:

 

  • NASI-Reliance Platinum Jubilee Award 2017 for application oriented research in the area of biological sciences.

 

  • Awarded DHR fellowship by Indian Council of Medical Research, India in March 2012 to work as visiting scientist at NIAID, NIH, Maryland USA

 

  • Qualified the Graduate Aptitude Test in Engineering (GATE) 1993 with a percentile score of 84.62 to avail UGC fellowship.

 

  • Life member of Indian Association of Medical Microbiologists (IAMM) since1994.

 

  • Elected member of National Academy of Science of India (NASI) since 2015

 

  • Elected member of National Academy of Medical Sciences of India (NAMAS) since 2015

Research activities

  • Anti-infective research for identification of novel scaffolds

My group has accomplished whole cell screening of large chemical libraries (50,000 compounds) against Mycobacterium tuberculosis, which has resulted in the identification of several novel scaffolds. The screening also employed streptomycin dependent M tuberculosis 18b which is absence of streptomycin behaves like non replicating latent M tb. Medicinal chemistry programs have been evolved to work around the identified scaffolds to develop lead candidates

 

  • Antimicrobial resistance and bacterial efflux pumps

Drug efflux is one of the major cause resistances in microorganisms. Our group is working bacterial trying to address the issue of emergence of drug resistance through efflux pumps inhibitors. We have a panel of efflux pumps overexpressing S aureus which are used to screen compound libraries and natural products as efflux pump inhibitors.

 

  • Target based drug discovery

We have cloned, expressed and established several target based assays such as GlmU, Shikimate kinase and ATP synthase of M. tuberculosis.

 

IND studies undertaken

  • ICB-014-A002: A botanical drug product for the management of peptic ulcers: IND filed in AYUSH, Phase I permission granted on Jan 2017. Current status: Phase I studies completed.
  • IIIM-0160-A002 for the management of pain in rheumatoid arthritis: Status: IND filed
  • Mupirocin + IIIM-1133: A topical formulation for improved bioefficacy:  Status: Ready for IND filing

 

Technologies commercialized

  • ICB-014-A002: A botanical drug product for the management of peptic ulcers: As nutraceutical supplement: Virdis BioPharma Pvt Ltd, Mumbai

 

Supervision of research

  • PhD Thesis awarded: 15
S. No. Authors Title of Article Journal/Conference Details Journal/Conference Publication Year
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Ongoing

  • Creation of ABSL-3 facility at CURAJ under Rajasthan bio-cluster for infectious diseases therapeutics and diagnostics- SERB-IRHPA-PI
  • Targeting the frameshifting site of SARS-CoV2 RNA genome with focused RNA libraries using dual-luciferase reporter assay- SERB-CRG-Co-PI

 

Completed

  • Production of bio-cellulose membrane under the purview of development and application of topical antibiotic based transdermal patches, DBT, (2017-2020), Co-PI

 

  • Identification of novel inhibitors of the GlmU in Mycobacterium tuberculosis. DHR, (2015-2018), PI
  • Synthesis and development of antitubercular 1,4-Napthoquinone congeners as Mycobacterium tuberculosis Methionine Aminopeptidases inhibitors, DBT, (2012-2015), Co-PI
  • Synthesis and antitubercular activity of Benzothiadiazine, Cumarin and Diarlypyrrolecongeners, DST, (2009-2012), Co-PI
  • Identification of Mycobacterium tuberculosis genes differentially expressed in TB patients

DST, (2009-2012), PI

 

Attended

Oral Presentation

  • Invited plenary speaker “ BSL-3 facility set-up and biosafety guidance to COVID-19” at Hands on Training and Workshop on PCR and Real Time PCR at CSIR-IIIM, Jammu under CSIR-Skill Development Program from 1st – 5th March 2021

 

  • Invited plenary speaker “ Addressing problems of antimicrobial resistance by natural products” at 22nd ADNAT Convention International symposium on Antimicrobial Resistance (AROHP) at IIT-Roorkee from 5th to 8th March 2019.

 

  • Presented a paper on " Ribotyping of Salmonella typhi in New Delhi INDIA" at XX National Congress of Indian Association of Medical Microbiologists, Agra, 1996.

 

  • Presented a paper on " Molecular fingerprinting of Salmonella typhi" at XIX National Congress of Indian Association of Medical Microbiologists, Pondicherry, 1995.

Poster Presentation

  • Diksha Raina, Farrah Gul Khan, Saurabh Saran, Inshad Ali Khan*. “Identification of inhibitors targeting Escherichia coli UDP-N-Acetylglucosamine Enolpyruvyl Transferase (MurA) enzyme by screening library compounds. Poster presented at AIIMS-ASM 2020 held on 7th -8th Oct 2020, AIIMS, New Delhi

 

  • Naveen Prakash Bokolia and Inshad Ali Khan* Co-transcriptional cleavage activity regulates gene expression of polyphosphate glucokiase in M tuberculosis H37Rv. Poster presented at International Conference on Molecular basis of diseases and therapeutics held on 8th to 10th March 2019, Central University of Rajasthan.

 

  • Samsher Singh,  A Wani, Ajay Mahajan, Sunil Kumar, Surrinder Koul, Inshad Ali Khan* IIIM-1132; a potent inhibitor as bioefficacy and a bioavailability enhancer of anti-cancer and anti-TB drugs. Poster presented at ASM Microbe 2017 held on 1-5 June 2017, New Orleans LA, USA

 

  • Samsher Singh, Sonali Bharate Vikas Kumar, Parduman Sharma, Sandeep Bharate, Inshad Ali Khan* Boeravinone B, a natural rotenoid from Boerhavia diffusa as novel inhibitor of MedA efflux pump of Staphylococcus aureus. Poster presented at ASM Microbe 2017 held on 1-5 June 2017, New Orleans LA, USA

 

  • Sunil Kumar Bhola and Inshad Ali Khan* New antibacterial agent targeting the mycobacterial ATP synthase. Poster presented at 17th Congress on Infectious Diseases-ICID  2nd to 5th March 2016, NIPER-Hyderabad

 

  • Samsher Singh, Gurunadham Munagala, Kushalava Yempalla Reddy, Sunil Kumar, Reena Chib, Rashmi Sharma, Chitra Rani, Parvinder Pal Singh, Ram A Vishwakarma, Inshad Ali Khan*. Biological evaluation of a novel nitroimidazooxazole derivative, IIIM-MCD-019 against Mycobacterium tuberculosis and its in vivo efficacy. Poster presented at 17th Congress on Infectious Diseases-ICID  2nd to 5th March 2016, NIPER-Hyderabad

 

  • Gurunadham Mungala, Kushalava Reddy Yempalla, Srinivas Ambala, Samsher Singh, Inshad Ali Khan, Ram A. Vishwakarma and Parvinder Pal Singh. MedicinalChemistry on Nitroimidazooxazolines: Triazolyl Containing 6-nitro-2, 3-dihydroimidazooxazole Compounds as Newer Generation Anti-TB Agents. Poster presented at International Conference on Drugs for future: infectious diseases-DFID-2014, 27th-28th March 2014, NIPER-Hyderabad.

 

  • Vikrant S. Rajput, Sanjay Kumar, Parvinder P. Singh & Inshad Ali Khan*. Screening and identification of inhibitors of shikimate kinase of  Mycobacterium tuberculosis from whole cell active library. Poster presented at International Conference on Drugs for future: infectious diseases-DFID-2014, 27th-28th March 2014, NIPER-Hyderabad.

 

  • Chitra Rani & Inshad Ali Khan*. Screening of chemical library for the identification of inhibitors of acetyltransferase domain of Mycobacterium tuberculosis GlmU. Poster presented at International Conference on Drugs for future: infectious diseases-DFID-2014, 27th-28th March 2014, NIPER-Hyderabad.

 

  • Rashmi Sharma, Chitra Rani & Inshad Ali Khan*. High Throughput Screening Identifies Novel Inhibitors of Acetyltransferase Activity of Escherichia coli GlmU. Poster presented at International Conference on Drugs for future: infectious diseases-DFID-2014, 27th-28th March 2014, NIPER-Hyderabad.

 

  • Shaik Azeeza, Valentina Dona, Kriti Arora, Inshad A Khan, Helena I Boshoff and Clifton E Barry III. Synthesis and Structure Activity Relationship of 5 hydroxy indole Derivatives as New Anti Tuberculosis Agents. Poster presented at Second UK-INDIA MedChem Congress 22nd-23rd March 2013 CSIR Indian Institute of Chemical Technology, Hyderabad, INDIA (Royal Society of Chemistry).

 

  • Nitin Pal Kalia,  Sandeep Sharma, Rukmankesh, Amit Nargotra, Buddh Singh, Surrinder Koul, and Inshad Ali Khan*. Identification of novel inhibitors of putative multidrug resistant efflux pump Rv1258c of Mycobacterium tuberculosis Agents. Poster presented at Second UK-INDIA MedChem Congress 22nd-23rd March 2013 CSIR Indian Institute of Chemical Technology, Hyderabad, INDIA (Royal Society of Chemistry).

 

  • Rukmankesh, Amit Nargotra, Nitin Kalia, Inshad Ali Khan, Surrinder Koul, Ram Vishwakarma. Insilico models for virtual screening, identification and lead optimization of inhibitors of putative multidrug resistant efflux pump Rv1258c of Mycobacterium tuberculosis. Poster presented at International Conference on OSCAT, 22nd -25th February 2012, CSIR-Institute of Microbial Technology, Chandigarh.

 

  • S. Sharma, M. Kuamr, A.B. Ram, N.P. Kalia, J. Suri, A. Khajuria, P. Suden, S. Bani, P.S. Chauhan and I.A.Khan*. Immunomodulatory activity of piperine leading to enhanced protective efficacy of rifampicin against Mycobacterium tuberculosis infection. Poster presented at International symposium on TB diagnostic: Innovating to make an impact, ICGEB, December 16-17, 2010.

 

  • I. Ali, I.A. Khan*, F. Ali, T. Ismail, H.M. Sampat Kumar and G.N. Qazi. Hydroximoyl chloride: a novel synthetic molecule against fungal pathogens. Poster presented at International Congress of Environmental research organized by Birla Institute of Technology and Science Pilani (Goa), 18-20 December, 2008.

 

  • F. Ali, I.A. Khan*, S. Sharma, I. Ali, A. Kumar, A.F. Raja, K.A. Suri, B.D. Gupta, N, Kumar, P. Dutt and G.N. Qazi. Hydroxychavicol: a natural molecule from Piper betle against oral cavity pathogens. Poster presented at International Congress of Environmental research organized by Birla Institute of Technology and Science Pilani (Goa), 18-20 December, 2008.

 

  • S. Sharma, I.A.Khan*, M. Kumar and A.B. Ram. Piperine as bioefficacy enhancer of Rifampicin against Mycobacterium tuberculosis infection. Poster presented at International symposium on emerging trends in tuberculosis research: biomarkers, drugs and vaccines, ICGEB, New Delhi on December 1-3, 2008.

 

  • M. Kumar, I.A.Khan*, F.G.Khan, S. Sharma and G.N. Qazi. Identification of Mycobacterium tuberculosis genes uniquely expressed in tuberculosis patients. Poster presented at International symposium on emerging trends in tuberculosis research: biomarkers, drugs and vaccines, ICGEB, New Delhi on December 1-3, 2008.

 

  • A.F. Raja, I.A. Khan*, I. Ali, F. Ali, M. Kumar, A.R. Ram, B.A. Shah, S.C Taneja and G.N. Qazi. Antimicrobial activities of boswellic acids from Boswellia serrata. Poster presented at 48th annual conference of association of microbiologists of India, Chennai, 18-21 December 2007.

 

  • A. Kumar, I.A. Khan*, P.R. Sharma, I. Ali, A.F. Raja and G.N. Qazi. Nitrate reductase assay for antibiotic susceptibility determination of biofilm formed by Staphylococcus aureus. Poster presented at International Conference on New Horizons in Biotechnology (NHBT-2007), Trivandrum, 26-29 November 2007.

 

  • Kumar, M., I. A. Khan*, F. G. Khan, S. Sharma, A. B. Ram, and G. N. Qazi. An efficient and rapid mycobacterial DNA extraction method from clinical samples for early diagnosis of tuberculosis using polymerase chain reaction. Poster presented at. International Conference on New Horizons in Biotechnology (NHBT-2007), Trivandrum, 26-29 November 2007.

 

  • I.A. Khan*, F.G. Khan, M. Kumar, S. Sharma, L.R. Manhas, S. Bani, A. Koul and G.N. Qazi. Plants based immunomodulator as adjunct to anti TB drugs. Poster presented at International Symposium on new frontiers in tuberculosis research, ICGEB, New Delhi on December 4-6, 2006.

 

  • I.A.Khan*, Z.M. Mirza, I. Ali, V. Verma and G.N. Qazi. Piperine, a phytochemical potentiator of ciprofloxacin against Staphylococcus aureus. Poster presented at XXIX- National congress of Indian Association of Medical Microbiologists, Chennai, 21-23 October 2005

 

  • M. Kumar, I.A.Khan*, S. Sharma, V. Verma and G.N. Qazi. Application of nitrate reductase assay in microtitre formate for rapid MIC determination of Mycobacterium tuberculosis. Poster presented at XXIX- National congress of Indian Association of Medical Microbiologists, Chennai, 21-23 October 2005.

 

  • I.A. Khan*, S. Koul, S.C. Taneja, A. Kumar, I. Ali, V. Verma and G.N. Qazi. SK-20- Potentiator of mupirocin’s activity. Poster presented at 46th annual conference of association of microbiologists of India, Hyderabad, 8-10 December 2005.

* Corresponding author

 

BSL-3 lab training

  • BSL-3 onsite biosafety training program conducted by Emory University, NSITE, USA at NIV Pune from 9th Feb to 13th Feb 2009.
  • Controlling Laboratory Biorisks Training Course conducted by International Biological Threat Reduction, Sandia National Laboratories at Albuquerque, USA from 27th April to 2 May 2009.
  • Six months working experience in BSL-3 lab at NIAID, NIH, Maryland, USA from 26th Dec 2012 to 25th June 2013.

 

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Patents and Publications PDF icon Patents and Publications.pdf